While many celebrities choose to spend their free time indulging in excess, filling in on “Hollywood Squares” and becoming objects of affection for the paparazzi, a few others are spawning entirely new and separate careers after achieving initial fame. Whether it’s clothing lines, cookware or coffeehouses, the celebrities listed here by Inside CRM Editors have hit the entrepreneurial jackpot.

Helena Christensen
This Danish model possesses beauty and business savvy. Christensen and her floral designer friend, Leif Sigersen opened BUTIK Christensen & Sigersen in New York City’s West Village in 2005. In addition to clothes, BUTIK also has a workshop for the pair to design clothing for the label they launched in 2006 and an area for floral designs.

Kate Moss
This other model-turned-designer and sometimes party girl launched a fashion line with British retailer Topshop last year. Summer and fall collections followed with accolades from industry pundits. Moss uses the fashion sense she mined from modeling to create her designs.

Kathy Ireland
The supermodel’s clothing line started in 1993 with a line of socks by Moretz. The $1.4 billion Kathy Ireland Worldwide label has expanded to stylish, yet affordable, home furnishings, books and exercise videos, flooring, lighting, and window treatments.

Christy Turlington Burns
Christy Turlington invites folks to get comfy as they contort with Nuala, her yoga-centric clothing and footwear line launched with Puma AG in 1999. That same year, Turlington also helped found natural skin-care company Sundari. Turlington’s endeavors have attracted a following among the environmentally conscious crowd. In particular, Nuala, which is an acronym for “natural, universal, altruistic, limitless and authentic,” fits the bill by donating portions of profits to anti-landmine groups, breast cancer research and UNICEF.

Madonna
Boy, does this woman have staying power! Dozens of hits, several controversies, styles and children later, the Queen of Pop recently made her mark on the fashion world with her clothing line. The nearly 50-year-old star teamed up with low-cost, high-fashion retailer H&M AB to sell her line in their stores in 26 countries.

Jennifer Lopez
The singer and actress’s transformation from fly girl to fashion mogul is an impressive one. She teamed up with Tommy Hilfiger’s Andy to found Sweetface Fashion Company in 2001. The label also makes fragrances, eyeglasses, jewelry, watches and footwear. Lopez now boasts retail boutiques across the U.S. and throughout the world. She also has a teen clothing line.

Gwen Stefani
This funky, yet feminine leader of the band No Doubt founded L-A-M-B Inc. in 2004. The brand provides popular clothing and footwear that reflect Stefani’s style and appeal to young women and girls. She also has a line of “Huckleberry Dolls,” miniature representations of Stefani that are sold through Target Corp. and other retailers.

Bono
The lead singer of U2 elevated his status when he founded Elevation Partners in 2004. The $1.9 billion firm makes large-scale investments in select media and entertainment companies and has so far partnered with Forbes LLC, video game maker BioWare/Pandemic Studios and the real estate Web site Move Inc.
In 2005, Bono founded EDUN, a for-profit fair trade group that sells clothing made in the developing world. Bono has also expressed interest in real estate, restaurants, hotels and a recording studio undergoing construction in Dublin.

Oprah Winfrey
Oprah’s tale is truly one of rags to riches. The TV talk host is now one of the richest and most powerful women in the world, thanks to her $290 million media empire. Harpo Entertainment Group sprung in 1988, just two years after The Oprah Winfrey Show took off.
For those who’d rather read than watch the boob tube, there’s O, The Oprah Magazine, which includes lifestyle articles geared toward women. In 1998, she co-founded Oxygen Media, a cable network targeted at women, and has commandeered several satellite radio and film productions.

Paul Newman
Newman’s Own Inc. offers a line of salad dressings and other foods that the legendary 82-year-old actor founded in 1982. The company’s natural-foods division, Newman’s Own Organics, sprouted in 1993 and includes steak sauce, salsa and juice drinks. Newman has donated $200 million in after-tax profits to charity, including the Hole in the Wall Gang Camp he founded for sick children.

Clint Eastwood
The former mayor of Carmel, Calif. started his flagship Mission Ranch Resort Hotel and restaurant there. Eastwood is also a partner in the nearby Pebble Beach golf course and resort and has been involved in several development projects in the area. He also runs a production company, Malpaso Productions Inc.

Lisa Rinna
The Days of Our Lives, Melrose Place and Dancing with the Stars actress founded boutiques in Sherman Oaks Calif. and Calabasas, Calif. three years ago with her husband, actor Harry Hamlin. Juicy Couture, Paige Premium Denim and her own belle gray label hang from the racks.

Phoebe Cates
Actress Phoebe Cates hasn’t appeared in a movie in some time, but her business savvy hasn’t disappeared. She opened her small boutique blue tree Inc. on Madison Avenue in New York City’s Upper East Side in October 2005. It sells high-end clothing, gifts and household items. Cates is often the worker ringing up sales at the register.

Merv Griffin
The Wheel of Fortune and  Jeopardy game show creator’s company oversaw film and TV production, real-estate development and hotels. Before his death in 2007, Griffin donated a property worth $10 million to Childhelp, which converted it to a treatment center for abused children.

Suzanne Somers
Somers played a blonde ditz on Three’s Company, but she’s proven that when it comes to the entrepreneurial spirit, she’s no dummy. She’s sold more than 10 million of her leg-slimming ThighMaster device and owns a dozen clothing, jewelry, food and beauty lines. She’s a popular seller on the Home Shopping Network, where her signature Trilliant bracelet is the best-selling jewelry piece to ever gleam and glitter on the show.

Danny DeVito
The vertically challenged comedian opened an Italian restaurant, DeVito South Beach, in Miami. And if it were a BYOB kind of place, he’d also have the liquor for you to bring. When he appeared rather tipsy on The View recently, DeVito claimed that George Clooney had kept him up drinking limoncello the night before. DeVito launched his own line of the lemon-flavored liqueur summer of 2008.

Mary Kate and Ashley Olsen
The strawberry-blonde twins, best known for playing adorable Michelle on the sitcom Full House, have ranked in Forbes’s “Celebrity 100 List” since they were 16 years old. Their image became heavily merchandised in the 1990s and came to include dolls, video series and clothing lines. Their brand has been sold in more than 3,000 stores in America and more than 5,300 stores worldwide. Forbes ranked them in 2007, collectively, as the 11th-richest women in entertainment, with an estimated net worth of $100 million.

Francis Ford Coppola
 Want to relax in front of one of this famous director’s movies with a bottle of wine? Try out some of his wine of his same name. Francis Ford Coppola Presents LLC is the umbrella group for his many diverse ventures, including a vineyard he owns in Napa Valley, Calif.; a gourmet Italian food line; resorts in Belize and Guatemala; a pair of cafés in San Francisco and Palo Alto, Calif.; and Zoetrope: All Story, a journal for emerging fiction writers and artists.